Telomerase Inhibition in Cancer Therapeutics: Molecular-Based Approaches
نویسندگان
چکیده
منابع مشابه
Telomere and Telomerase Therapeutics in Cancer
Telomerase is a reverse transcriptase capable of utilizing an integrated RNA component as a template to add protective tandem telomeric single strand DNA repeats, TTAGGG, to the ends of chromosomes. Telomere dysfunction and telomerase reactivation are observed in approximately 90% of human cancers; hence, telomerase activation plays a unique role as a nearly universal step on the path to malign...
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ژورنال
عنوان ژورنال: Current Medicinal Chemistry
سال: 2006
ISSN: 0929-8673
DOI: 10.2174/092986706778521887